sábado, 15 de febrero de 2014

Postdoctoral position in Translational Genomics (Deadline for application: 24th February)

The Translational Genomics Group of the INCLIVA health research institute (Valencia, Spain) is seeking candidates interested in applying for a 2 year postdoctoral award by the Spanish government (deadline February 24th). Eligible candidates must have obtained their PhD degree after September 2009. More information, in Spanish, can be found here http://www.boe.es/diario_boe/txt.php?id=BOE-A-2013-13832. Note that Spanish citizenship is not required. Potentially interested candidates are encouraged to contact Ruben Artero (ruben.artero@uv.es) urgently. Research interests of the group are: (1) discovery of inhibitors of HER2 dimerization, (2) drug discovery in Spinal Muscular Atrophy and (3) mechanisms of pathogenesis in Myotonic Dystrophy and exploration of therapeutic approaches. The group has a strong focus on translational research and maintains collaborations with biotechnology companies such as Valentia BioPharma and Instituto de Medicina Genómica at the Science Park of the University of Valencia.

Recent publications by the group
Garcia-Alcover I, López Castel A, Perez-Alonso M, Artero R. (2013). In vivo strategies for drug discovery in myotonic dystrophy disorders. Drug Discov Today Technol. 10(1):e97-102. doi: 10.1016/j.ddtec.2012.02.001.
Fernandez-Costa JM, Garcia-Lopez A, Zuñiga S, Fernandez-Pedrosa V, Felipo-Benavent A, Mata M, Jaka O, Aiastui A, Hernandez-Torres F, Aguado B, Perez-Alonso M, Vilchez JJ, Lopez de Munain A, Artero RD. (2013). Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients. Hum Mol Genet. 2013 Feb 15;22(4):704-16. doi: 10.1093/hmg/dds47.
Llamusi B, Bargiela A, Fernandez-Costa JM, Garcia-Lopez A, Klima R, Feiguin F, Artero R. (2013). Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model. Dis Model Mech. 6(1):184-96. doi: 10.1242/dmm.009563
Garcia-Lopez A, Llamusi B, Orzaez M, Perez-Paya E, Artero RD (2011). In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models. Proc Natl Acad Sci U S A. 108(29):11866-71.
Weavers H, Prieto-Sanchez S, Grawe F, Garcia-Lopez A, Artero R, Wilsch-Bräuninger M, Ruiz-Gomez M, Skaer H, Denholm B. (2009). The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm. Nature. 15;457(7227):322-6.
Garcia-Lopez A, Monferrer L, Garcia-Alcover I, Vicente-Crespo M, Alvarez-Abril MC, Artero RD. Genetic and chemical modifiers of a CUG toxicity model in Drosophila. PLoS One. 2008 Feb 13;3(2):e1595.

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